Pomella™ Natural Pomegranate extract 250 mg veg capsules,60 Nos/bottle, Antioxidant

What is Pomella

Pomella Pomegranate Extract is a breakthrough formula standardized to Punicalagins the primary natural antioxidants of the pomegranate fruit.

Systemic Health :

Protects against Oxidative and Carbonyl Stress causing a systemic protective effect

Increases antioxidant activity in the blood (Up to  32%  with a single dose)

Exhibits  significantly higher antioxidant capacity than grape seed, green tea, and other polyphenols.

Joint Health :

Protects against loss of type 2 collagen

Downregulates MMP-2, MMP-9, and MMP-13 reducing cartilage degradation

Prevents accumulation of Advance Glycation End products in joint chondrocytes, preventing oxidative damage

Skin Health

Protects against UV Induced oxidative stress

Reduces breakdown of collagen by downregulating production of MMPs

Down regulates inflammatory response by inhibiting the activation NF- k

Pomella Pomegranate Extract is a breakthrough formula standardized to Punicalagins the primary natural antioxidants of the pomegranate fruit.

Punicalagins are the main Ellagitannin polyphenols and are among the most ferocious scavengers of free radicals. Punicalagins are unique in that they are further metabolised to bioactive compounds absorbed into target tissues. Punicalagins are also potent modulators of inflammation and cellular signalling.

It was found that metabolites (Ellagic acid) are not absorbed when consumed in free form and need to be attached to the parent polyphenol to be bioavailable. The remarkable synergy of punicalagins within the pomegranate’s natural spectrum of ellagitannins, explains the potency of Pomella Extract.

Anti-Glycation End Products (AGEs)

AGE’s are implicated in numerous age-related diseases. Research shows accumulation of AGEs in cartilage chondrocytes leads to decreased proteoglycan and collagen synthesis. This in turn leads to stiffness and brittleness of the articular cartilage. AGEs can also up-regulate the production of MMPs that mediate cartilage degradation leading to joint destruction10.AGE’s have also been implicated in Cognitive Health decline. Pomella was studied in the gut brain model, looking specifically at AGE’s where Pomella was shown to work better than the control in a concentration-dependent manner.

Nitric Oxide

Nitric oxide (NO) is the most important endothelium-dependent vasodilator produced by endothelial nitric oxide synthase (eNOS) in the blood vessels. Nitric oxide bioavailability is also important for healthy joints due to the role as mediator of vasodilation, inflammation, and pain perception. Evidence suggests that pomegranate can improve nitric oxide bioavailability and NO-mediated endothelial function. Punicalagins and its metabolites, such as urolithins, can increase the bioactivity of eNOS. The antioxidant property of Pomella also prevents the oxidative destruction of eNOS.

Reactive species

Reactive species like ROS,RNS and Reactive Carbonyl species are normal intermediates in the metabolic processes in the body. These are volatile free radicals which have the potential to bind with proteins to disrupt normal physiological processes. These are normally neutralised by the bodies anti-oxidant system. When the delicate balance of antioxidants and Reactive species is disturbed it may lead to chronic inflammation and disease. Researchers tested many potential candidates and found that Punicalagins top the list in antioxidant activity. In healthy human volunteers, a single dose of Pomella® led to a significant 32% increase of antioxidant activity in the blood. Metabolites of punicalagins have been detected in the body up to 48-hours after consumption2.

Applications of Pomella

Systemic Health :

Pomella protects against Oxidative and Carbonyl Stress which can have detrimental long term effects like Mitochondrial dysfunction, Cellular senescence, Genome instability, chronic inflammation and loss of proteostasis. These effects have a big role in degenerative diseases like osteoarthritis and Alzheimer’s disease.

Joint Health

Adequate amounts of cartilage and the lubrication by hyaluronic acid are integral to joint health. Cartilage destruction is a key component in many joint specific ailments, and it is characterized by the degradation of cartilage proteins, proteoglycans, and type II collagen which makes up 50% of cartilage protein. The natural ability to regenerate collagen decreases progressively with age. Nitric oxide bioavailability is also important for healthy joints due to the role as mediator of vasodilation, inflammation, and pain perception.

Researchers at the University of Rhode Island examined the role of Pomella® Extract in a cartilage degradation model, and found protective effects on collagen through inhibition of the collagenases MMP-2, MMP-9, and MMP-13. They go on to explain that, “while proteoglycan loss can be reversed, the degradation of type II collagen is irreversible”. If left untreated, isolated cartilage lesions can lead to progressive global cartilage loss over time.

Pomella prevents accumulation of Advance Glycation End products in joint chondrocytes, preventing oxidative damage and cartilage degradation.

Endothelial Health

Nitric oxide (NO) is the most important endothelium-dependent vasodilator produced by endothelial nitric oxide synthase (eNOS) in the blood vessels. Evidence suggests that pomegranate can improve nitric oxide bioavailability and NO-mediated endothelial function. Punicalagins and its metabolites, such as urolithins, can increase the bioactivity of eNOS. The antioxidant property of Pomella also prevents the oxidative destruction of eNOS. Pomella also downregulates Homocysteine production preventing vascular injury and plaque formation.

Brain Health

There is General agreement on the role the gut microflora can play in protecting and improving cognition and brain function. Researchers at the University of Rhode Island have found that gut microflora metabolises punicalagins into the bioactive metabolites urolithins, which have the ability to cross the blood brain barrier. Urolithins prevent accumulation of AGEs, a major cause of Neuro degeneration in the brain

These researchers also developed a Neuroprotective Potential Algorithm (NPA) to evaluate plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholine- esterase (AChE) inhibition, and neuroinflammation. Pomella was ranked in the top three extracts offering best in class Neuroprotective potential.

Metabolic Health

Human trials with Pomella have shown significant reduction in Hb1Ac readings in patients with Myocardial Infarction within 30 days supplementation. Other observations were improved Lipid profile with decrease in LDL and ox-LDL cholesterol. Pomella has been also shown to have a prebiotic effect on gut microbiome, having a significant positive influence on the the Gut Brain and Gut skin axis.

Skin Health

When skin is exposed to oxidative stress, the effectiveness of the endogenic antioxidant system can be significantly compromised. Oxidative stress is responsible for inflammation, immunosuppression, oxidative DNA damage, and increased expression of metalloproteinases (MMPs) that are responsible for collagen degradation. Pomella downregulates the inflammatory response by inhibiting the activation of transcription factor nuclear factor-kB (NF- kB).Pomella protects against skin ageing and damage by helping reduce collagen degradation.

In summary

Pomella is a powerful antioxidant which prevents damage from oxidative and Glycative stress

Pomella prevents the formation and impact of AGEs

Pomella prevents Collagen damage in joints and skin

Pomella has proven protective effects from UV induced damage

Pomella has known to help glucose management in diabetic patients